A practicable environmentally benign one-pot synthesis of 2-arylbenzofurans at room temperatureElectronic supplementary information (ESI) available: Characterization data for known benzofurans and NMR spectra for all compounds. See DOI: 10.1039/c2gc16181h

An environmentallyfriendly one-pot synthesis of 2-arylbenzofurans under ambient temperature has been developed. It features an ortho -hydroxyl group assisted Wittig reaction of substituted salicylaldehyde followed by an in situ oxidative cyclization. Its advantages include readily available and non-...

Full description

Saved in:
Bibliographic Details
Main Authors Liao, Lian-Yan, Shen, Gang, Zhang, Xue, Duan, Xin-Fang
Format Journal Article
LanguageEnglish
Published 03.01.2012
Online AccessGet full text

Cover

More Information
Summary:An environmentallyfriendly one-pot synthesis of 2-arylbenzofurans under ambient temperature has been developed. It features an ortho -hydroxyl group assisted Wittig reaction of substituted salicylaldehyde followed by an in situ oxidative cyclization. Its advantages include readily available and non-hazardous materials, benign reaction conditions (room temperature, green solvent and one-pot manner), easy work-up and high overall yields. Utilizing this methodology, various 2-aryl-benzofurans including four natural products have been synthesized. A simple, practicable and environmentally friendly protocol for the one-pot synthesis of 2-arylbenzofurans under benign conditions has been developed.
Bibliography:10.1039/c2gc16181h
Electronic supplementary information (ESI) available: Characterization data for known benzofurans and NMR spectra for all compounds. See DOI
ISSN:1463-9262
1463-9270
DOI:10.1039/c2gc16181h