Interactions of marine-derived γ-pyrone natural products with phospholipid membranesElectronic supplementary information (ESI) available: Materials, experimental details, CMC data, UV spectra. See DOI: 10.1039/c2cp42920a

The sacoglossan mollusc-derived metabolite, tridachiahydropyrone ( 3 ), and its proposed biosynthetic precursors ( 1 and 2 ) form part of a complex chemical defence system against predators and harmful UV light. Here, we provide supporting biophysical evidence that the metabolites become selectively...

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Bibliographic Details
Main Authors Powell, Kimberley J, Sharma, Pallavi, Richens, Joanna L, Davis, Benjamin M, Moses, John E, O'Shea, Paul
Format Journal Article
LanguageEnglish
Published 10.10.2012
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Summary:The sacoglossan mollusc-derived metabolite, tridachiahydropyrone ( 3 ), and its proposed biosynthetic precursors ( 1 and 2 ) form part of a complex chemical defence system against predators and harmful UV light. Here, we provide supporting biophysical evidence that the metabolites become selectively localised at cell membranes and outline a binding scheme that accommodates the observed data. The possibility that localised lipid domains within the membrane have an effect on the localisation is also addressed. The article provides supporting biophysical evidence that the sacoglossan mollusc-derived metabolite, tridachiahydropyrone ( 3 ) and its proposed biosynthetic precursors ( 1 and 2 ), become selectively localised at the cell membrane, where they perhaps serve as natural sunscreen.
Bibliography:10.1039/c2cp42920a
Electronic supplementary information (ESI) available: Materials, experimental details, CMC data, UV spectra. See DOI
ISSN:1463-9076
1463-9084
DOI:10.1039/c2cp42920a