A two-photon fluorescent probe for amyloid-β plaques in living miceElectronic supplementary information (ESI) available. See DOI: 10.1039/c2cc38570h

We report a small molecule two-photon probe (SAD1) that shows a significant TP action cross section (170 GM), binds to Aβ plaques specifically, readily enters the brain through the BBB, and can directly 3D monitor the individual Aβ plaque in living transgenic mice at more than 380 μm depths. We repo...

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Main Authors Heo, Cheol Ho, Kim, Kyung Ho, Kim, Hyung Joong, Baik, Sung Hoon, Song, Hyundong, Kim, Yong Soo, Lee, Jeewoo, Mook-jung, Inhee, Kim, Hwan Myung
Format Journal Article
LanguageEnglish
Published 17.01.2013
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Summary:We report a small molecule two-photon probe (SAD1) that shows a significant TP action cross section (170 GM), binds to Aβ plaques specifically, readily enters the brain through the BBB, and can directly 3D monitor the individual Aβ plaque in living transgenic mice at more than 380 μm depths. We report a small molecule two-photon probe (SAD1) that can directly 3D monitor the individual Aβ plaque in living transgenic mice at more than 380 μm depths.
Bibliography:10.1039/c2cc38570h
Electronic supplementary information (ESI) available. See DOI
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc38570h