Nanoparticles act as protein carriers during cellular internalizationElectronic supplementary information (ESI) available: Detailed experimental methods and supplementary figures. See DOI: 10.1039/c2cc16937a

Two-colour fluorescence microscopy was used to track the cellular internalization of nanoparticles exposed to extracellular serum proteins. Single particle tracking revealed that nanoparticles and serum proteins are internalized and transported through the cell as a single complex. This study demons...

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Bibliographic Details
Main Authors Doorley, Gerard W, Payne, Christine K
Format Journal Article
LanguageEnglish
Published 22.02.2012
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Summary:Two-colour fluorescence microscopy was used to track the cellular internalization of nanoparticles exposed to extracellular serum proteins. Single particle tracking revealed that nanoparticles and serum proteins are internalized and transported through the cell as a single complex. This study demonstrates the importance of nanoparticle-protein interactions in cellular applications. Nanoparticles associate with serum proteins in solution and are internalized and transported through cells as a serum protein-nanoparticle complex.
Bibliography:Electronic supplementary information (ESI) available: Detailed experimental methods and supplementary figures. See DOI
10.1039/c2cc16937a
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc16937a