hydroxy ketones prepared by regioselective hydroacylationElectronic supplementary information (ESI) available: Experimental procedures, characterization data for new compounds. See DOI: 10.1039/c1sc00634g
We report an intermolecular hydroacylation of allylic alcohols with salicylaldehydes to afford -hydroxy aryl ketones in 7394% yields as single regioisomers. The reactivity and regioselectivity were promoted by catalytic amounts of a phosphinite that forms a dynamic covalent bond with the allylic alc...
Saved in:
Main Authors | , , |
---|---|
Format | Journal Article |
Language | English |
Published |
10.01.2012
|
Online Access | Get full text |
Cover
Loading…
Summary: | We report an intermolecular hydroacylation of allylic alcohols with salicylaldehydes to afford -hydroxy aryl ketones in 7394% yields as single regioisomers. The reactivity and regioselectivity were promoted by catalytic amounts of a phosphinite that forms a dynamic covalent bond with the allylic alcohol. Hydroacylation of 1,2- and 1,1-disubstituted olefins generates -hydroxy aryl ketones bearing tertiary and quaternary centers, respectively.
By applying cooperative catalysis, we achieve a regioselective hydroacylation of allylic alcohols to afford formal aldol products. |
---|---|
Bibliography: | 10.1039/c1sc00634g Electronic supplementary information (ESI) available: Experimental procedures, characterization data for new compounds. See DOI |
ISSN: | 2041-6520 2041-6539 |
DOI: | 10.1039/c1sc00634g |