The biodistribution of maltotriose modified poly(propylene imine) (PPI) dendrimers conjugated with fluoresceinproofs of crossing bloodbrainbarrierThis article is part of the themed issue Dendrimers II, guest-edited by Jean-Pierre Majoral

Oligosaccharide-modified poly(propylene imine) dendrimers are promising candidates as drug carriers and as anti-prion agents. Here, we report the biodistribution of maltotriose-modified 4th generation poly(propylene imine) (PPI) dendrimers and their ability to cross the bloodbrainbarrier that is imp...

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Bibliographic Details
Main Authors Janaszewska, A, Ziemba, B, Ciepluch, K, Appelhans, D, Voit, B, Klajnert, B, Bryszewska, M
Format Journal Article
LanguageEnglish
Published 24.01.2012
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Summary:Oligosaccharide-modified poly(propylene imine) dendrimers are promising candidates as drug carriers and as anti-prion agents. Here, we report the biodistribution of maltotriose-modified 4th generation poly(propylene imine) (PPI) dendrimers and their ability to cross the bloodbrainbarrier that is important if these glycodendrimers are considered as potential therapeutic agents in the central nervous system (CNS). The biodistribution of maltotriose modified PPI dendrimers with a special attention paid to the BBB crossing was studied. The dendrimers were able to enter rats important organs including the brain.
Bibliography:This article is part of the themed issue Dendrimers II, guest-edited by Jean-Pierre Majoral.
ISSN:1144-0546
1369-9261
DOI:10.1039/c1nj20444k