Osmium(vi) complexes as a new class of potential anti-cancer agentsElectronic supplementary information (ESI) available: Experimental section, Fig. S1: stability evaluation of 1; Fig. S2 and S3: UV-visible spectral change of 1 in the presence of GSH and 5′-GMP; Fig. S4: cytotoxic profiles of 1 towards cancerous cell lines; Fig. S5: antiproliferative effects of 1 and cisplatin in HeLa and HepG2 for 72 h; Fig. S6: cytotoxic profiles of 1 and cisplatin towards CCD-19Lu cells; Fig. S7: flow cytometr

A nitridoosmium( vi ) complex [Os VI (N)(sap)(OH 2 )Cl] (H 2 sap = N -salicylidene-2-aminophenol) displays prominent in vitro and in vivo anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5′-guanosine monophosphate. A nitridoosmium( vi ) complex [Os VI...

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Main Authors Ni, Wen-Xiu, Man, Wai-Lun, Cheung, Myra Ting-Wai, Sun, Raymond Wai-Yin, Shu, Yuan-Lan, Lam, Yun-Wah, Che, Chi-Ming, Lau, Tai-Chu
Format Journal Article
LanguageEnglish
Published 01.02.2011
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Summary:A nitridoosmium( vi ) complex [Os VI (N)(sap)(OH 2 )Cl] (H 2 sap = N -salicylidene-2-aminophenol) displays prominent in vitro and in vivo anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5′-guanosine monophosphate. A nitridoosmium( vi ) complex [Os VI (N)(sap)(OH 2 )Cl] (H 2 sap = N -salicylidene-2-aminophenol) displays prominent in vitro and in vivo anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5′-guanosine monophosphate.
Bibliography:tumor growth inhibition study. See DOI
1
towards cancerous cell lines; Fig. S5: antiproliferative effects of
in the presence of GSH and 5′-GMP; Fig. S4: cytotoxic profiles of
Electronic supplementary information (ESI) available: Experimental section, Fig. S1: stability evaluation of
treated HeLa cells; Table S1
and cisplatin in HeLa and HepG2 for 72 h; Fig. S6: cytotoxic profiles of
10.1039/c0cc04515b
in vivo
Fig. S2 and S3: UV-visible spectral change of
and cisplatin towards CCD-19Lu cells; Fig. S7: flow cytometric data of
treated HeLa cells; Fig. S8: fluorescent microscopic examination of
ISSN:1359-7345
1364-548X
DOI:10.1039/c0cc04515b