Synthesis of an analogue of the bisphosphonate drug Ibandronate for targeted drug-delivery therapeutic strategiesThis article is part of a themed issue on Biophosphates.Electronic supplementary information (ESI) available: NMR data for compounds 1 and 3. See DOI: 10.1039/b9nj00597h

An analogue of the bisphosphonate drug Ibandronate was prepared and coupled via a cleavable ester function to a bromoacetyl linker with specific reactivity for thiol groups. This compound should find useful applications in therapeutic strategies aiming to deliver bisphosphonate drugs specifically to...

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Bibliographic Details
Main Authors Camper, Nicolas, Scott, Christopher J, Migaud, Marie E
Format Journal Article
LanguageEnglish
Published 01.05.2010
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Summary:An analogue of the bisphosphonate drug Ibandronate was prepared and coupled via a cleavable ester function to a bromoacetyl linker with specific reactivity for thiol groups. This compound should find useful applications in therapeutic strategies aiming to deliver bisphosphonate drugs specifically to cancer cells making use of proteins as vectors. The specific delivery of bisphosphonates to cancer cells instead of bone, the usual site of accumulation of these cytotoxic drugs, could greatly widen their therapeutic applications. The synthesis of an Ibandronate analogue attached by a cleavable ester group to a linker with thiol specific reactivity opens the way to the targeted delivery of bisphosphonates to cancer cells.
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10.1039/b9nj00597h
This article is part of a themed issue on Biophosphates.
Electronic supplementary information (ESI) available: NMR data for compounds
See DOI
ISSN:1144-0546
1369-9261
DOI:10.1039/b9nj00597h