Single nucleotide variants in the LR1, TLR2 and TLR6 genes: A case-control study in a Colombian population

Background: Single nucleotide variants in toll-like receptor genes play a crucial role in leprosy susceptibility or resistance. Methods: With an epidemiology case-control study, associations between SNVs rs5743618 in TLR1, rs5743708 in TLR2, and rs5743810 in TLR6 and overall susceptibility for lepro...

Full description

Saved in:
Bibliographic Details
Published inTropical medicine and infectious disease Vol. 8; no. 10; pp. 1 - 13
Main Authors Luz D Gutierrez-Castaneda, Carmen R Acosta, Monica A Bustos, Diana K Garcia, Diana P Bohada, Raul Rodriguez, Martha Inirida Guerrero
Format Journal Article
Published Basel, Switzerland MDPI 01.10.2023
Subjects
Analysis
Diseases
Leprosy
Mycobacterium leprae
Nerves, Peripheral
Nucleotides
Patients
Social conditions
Treatment
Online AccessGet full text
ISSN2414-6366
2414-6366
DOI10.3390/tropicalmed8100473

Cover

More Information
Summary:Background: Single nucleotide variants in toll-like receptor genes play a crucial role in leprosy susceptibility or resistance. Methods: With an epidemiology case-control study, associations between SNVs rs5743618 in TLR1, rs5743708 in TLR2, and rs5743810 in TLR6 and overall susceptibility for leprosy were estimated in 114 cases and 456 controls. Following that, stratified analysis was performed. DNA was extracted from peripheral blood. Genotyping was performed using predesigned TaqMan probes. Results: The A/G genotype of rs5743810 behaved as a protective factor for the development of leprosy in the codominant (OR= 0.37; 95% CI = 016-0.86, p = 0.049) and over-dominant (OR = 0.38; 95% CI = 0.16-0.88, p = 0.019) inheritance models. The A/G and A/A genotypes behaved as a protective factor (OR = 0.39; 95% CI = 0.17-0.87, p = 0.016) in the dominant model. The SNVs rs5743618 and rs5743708 showed no association with any of the mod- els. The CGG haplotype (rs5743618-rs5743708-rs5743810) behaved as a susceptibility factor for developing leprosy (OR = 1.86; 95% CI = 1.11-3.10, p = 0.019). The latter haplotype behaved as a susceptibility factor for leprosy development in women (OR = 2.39; 95% CI = 1.21-4.82, p = 0.013). Conclusions: The identified variants in the genes encoding TLRs, specifically rs5743810 in TLR6 and CGG (rs5743618-rs5743708-rs5743810) haplotypes, May somehow explain leprosy susceptibility in the studied population in a leprosy endemic region in Colombia.
Bibliography:Tropical Medicine and Infectious Disease, Vol. 8, No. 10, Oct 2023, 1-13
Informit, Melbourne (Vic)
ISSN:2414-6366
2414-6366
DOI:10.3390/tropicalmed8100473