Transcriptional dysregulation underlies both a monogenic arrhythmia syndrome and common modifier of cardiac repolarization

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Bibliographic Details
Published in	Circulation (New York, N.Y.) Vol. 147; no. 10; pp. 824 - 840
Main Authors	Bersell, Kevin R., Yang, Tao, Mosley, Jonathan D., Glazer, Andrew M., Hale, Andrew T., Kryshtal, Dmytro O., Kim, Kyungsoo, Steimle, Jeffrey D., Brown, Jonathan D., Salem, Joe-Elie, Campbell, Courtney C., Hong, Charles C., Wells, Quinn S., Johnson, Amanda N., Short, Laura, Blair, Marcia A., Behr, Elijah R., Petropoulou, Evmorfia, Jamshidi, Yalda, Benson, Mark D., Keyes, Michelle J., Ngo, Debby, Vasan, Ramachandran S., Yang, Qiong, Gerszten, Robert E., Shaffer, Christian, Parikh, Shan, Sheng, Quanhu, Kannankeril, Prince J., Moskowitz, Ivan P., York, John D., Wang, Thomas J., Knollmann, Bjorn C., Roden, Dan M.
Format	Journal Article
Language	English
Published	16.12.2022
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Bibliography:	Author contributions: K.R.B., T.Y., and D.M.R. conceived of and designed experiments. K.R.B., Q.S.W., P.J.K, C.C.H., E.R.B., E.P., Y.J., M.A.B., and L.S. identified and recruited study participants, generated iPSC lines, and edited iPSC genome using CRISPR/Cas9 system. K.R.B., C.C.C., A.N.J., A.M.G., and L.S biochemically characterized mutant TBX5 function. K.R.B., T.Y., S.P., K.K., D.O.K., B.C.K., and D.M.R performed, analyzed, and interpreted all electrophysiology experiments. J.E.S. performed and analyzed electrocardiographic analysis. A.T.H. and J.D.Y. performed and analyzed phosphoinositide labeling experiments. K.R.B., J.D.B., M.A.B., C.S., and Q.S. prepared samples for iPSC-CM RNA-sequencing and analyzed datasets. J.D.S. and I.P.M. performed and analyzed the murine RNA-sequencing experiments. J.D.M., A.M.G., K.R.B., M.D.B., M.J.K., D.N., R.S.V., Q.Y., R.E.G., G.P.J., B.N., M.F.M., and T.J.W. performed and analyzed plasma protein-related investigations. K.R.B. and D.M.R wrote the manuscript with input from all the authors.
ISSN:	0009-7322 1524-4539
DOI:	10.1161/CIRCULATIONAHA.122.062193