Decay of COVID-19 mRNA vaccine-induced immunity in people living with HIV

Current COVID-19 mRNA vaccines induce robust SARS-CoV-2-specific humoral and cellular responses in PLWH. However, the rate of decay of effector immune responses has not been studied in these individuals. Here we report a significant waning of antibody responses but persistent T cell responses six mo...

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Bibliographic Details
Published inAIDS (London) Vol. 36; no. 9; pp. 1315 - 1317
Main Authors WOLDEMESKEL, Bezawit A., KARABA, Andrew H., GARLISS, Caroline C., BECK, Evan J., AYTENFISU, Tihitina Y., JOHNSTON, Trevor S., LAEYENDECKER, Oliver, COX, Andrea L., BLANKSON, Joel N.
Format Journal Article
LanguageEnglish
Published 15.07.2022
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Summary:Current COVID-19 mRNA vaccines induce robust SARS-CoV-2-specific humoral and cellular responses in PLWH. However, the rate of decay of effector immune responses has not been studied in these individuals. Here we report a significant waning of antibody responses but persistent T cell responses six months post vaccination in virally suppressed PLWH with high CD4+ T cell counts. These responses are comparable to those seen in healthy donors.
ISSN:0269-9370
1473-5571
DOI:10.1097/QAD.0000000000003263