The Transcription Factor GATA4 Regulates Cell Type-Specific Splicing through Direct Interaction with RNA in Human iPS-Derived Cardiac Progenitors

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Published inCirculation (New York, N.Y.) Vol. 146; no. 10; pp. 770 - 787
Main Authors Zhu, Lili, Choudhary, Krishna, Gonzalez-Teran, Barbara, Ang, Yen-Sin, Thomas, Reuben, Stone, Nicole R., Liu, Lei, Zhou, Ping, Zhu, Chenchen, Ruan, Hongmei, Huang, Yu, Jin, Shibo, Pelonero, Angelo, Koback, Frances, Padmanabhan, Arun, Sadagopan, Nandhini, Hsu, Austin, Costa, Mauro W., Gifford, Casey A., van Bemmel, Joke, Hüttenhain, Ruth, Vedantham, Vasanth, Conklin, Bruce R., Black, Brian L., Bruneau, Benoit G., Steinmetz, Lars, Krogan, Nevan J., Pollard, Katherine S., Srivastava, Deepak
Format Journal Article
LanguageEnglish
Published 08.08.2022
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Bibliography:LZ and DS conceived the study, interpreted the data and wrote the manuscript. MWC interpreted the data and helped write the manuscript. YSA and BGT performed AP, and MS was done and analyzed by RH and NJK. KC, RT, KSP, LS, CZ, CG, AP, FK and JvB analyzed eCLIP, CHIP and RNA-Seq data. LZ, LL prepared the cells for eCLIP. LZ, PZ, and NS performed siRNA knockdown. HR planned, performed cellular electrophysiology assays and analyzed electrophysiology data. VV planned, electrophysiology assays, analyzed electrophysiology data, prepared the related figure, methods and results. LZ, MWC, AH, YH, AP and NS isolated the NRVMs. CZ and LS analyzed the RNA-Seq data. BGB, BLB and BRC helped plan and interpret use of human iPSCs and AP-MS results.
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ISSN:0009-7322
1524-4539
DOI:10.1161/CIRCULATIONAHA.121.057620