Long non-coding RNA H19 – a new player in the pathogenesis of liver diseases

The liver is a vital organ that controls glucose and lipid metabolism, hormone regulation, and bile secretion. Liver injury can occur from various insults such as viruses, metabolic diseases, and alcohol, which lead to acute and chronic liver diseases. Recent studies have demonstrated the implicatio...

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Bibliographic Details
Published inTranslational research : the journal of laboratory and clinical medicine Vol. 230; pp. 139 - 150
Main Authors Yang, Zhihong, Zhang, Ting, Han, Sen, Kusumanchi, Praveen, Huda, Nazmul, Jiang, Yanchao, Liangpunsakul, Suthat
Format Journal Article
LanguageEnglish
Published 20.11.2020
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Summary:The liver is a vital organ that controls glucose and lipid metabolism, hormone regulation, and bile secretion. Liver injury can occur from various insults such as viruses, metabolic diseases, and alcohol, which lead to acute and chronic liver diseases. Recent studies have demonstrated the implications of long non-coding RNAs (lncRNAs) in the pathogenesis of liver diseases. These newly discovered lncRNAs have various functions attributing to many cellular biological processes via distinct and diverse mechanisms. LncRNA H19, one of the first lncRNAs being identified, is highly expressed in fetal liver but not in adult normal liver. Its expression, however, is increased in liver diseases with various etiologies. In this review, we focused on the roles of H19 in the pathogenesis of liver diseases. This comprehensive review is aimed to provide useful perspectives and translational applications of H19 as a potential therapeutic target of liver diseases.
Bibliography:Roles of authors
ZY, SL: study concept and design, drafting of the manuscript; PK, TZ, SH, NH, YJ: critical revision of the manuscript and article queries. All authors have read and approved the manuscript for submission.
ISSN:1931-5244
1878-1810
DOI:10.1016/j.trsl.2020.11.010