Genomics of Black American Colon Cancer Disparities: An RNA-Seq Study from an Academic, Tertiary Referral Center

The incidence and mortality rate from colon cancer varies significantly between Black Americans (BA) and Non-Hispanic White Americans (NHWA). This study used RNA-Seq to identify difference in expression of 456 genes and 500 genetic pathways between BA and NHWA colon cancer specimens, which may help...

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Bibliographic Details
Published inSurgery Vol. 170; no. 4; pp. 1160 - 1167
Main Authors Haskins, Ivy N., Wang, Bi-Dar, Bernot, James P., Cauley, Edmund, Horvath, Anelia, Marks, John H, Lee, Norman H., Agarwal, Samir
Format Journal Article
LanguageEnglish
Published 18.05.2021
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Summary:The incidence and mortality rate from colon cancer varies significantly between Black Americans (BA) and Non-Hispanic White Americans (NHWA). This study used RNA-Seq to identify difference in expression of 456 genes and 500 genetic pathways between BA and NHWA colon cancer specimens, which may help to explain differences in the progression of colon cancer between these two populations.
ISSN:0039-6060
1532-7361
DOI:10.1016/j.surg.2021.03.031