Healthcare utilization and steroid-refractory toxicities from immune checkpoint inhibitors

Immune checkpoint inhibitors (ICI) cause immune-related toxicities; the rate of steroid refractory events, need for additional immunosuppression, and hospitalizations are not well described. We show that combination ICI is linked with higher rates of steroid refractory toxicities and healthcare util...

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Bibliographic Details
Published inCancer Vol. 126; no. 2; pp. 322 - 328
Main Authors Wang, Laura X., Quach, Henry T., Moodabigil, Nikil, Davis, Elizabeth J., Sosman, Jeffrey A., Dusetzina, Stacie B., Johnson, Douglas B.
Format Journal Article
LanguageEnglish
Published 03.10.2019
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Summary:Immune checkpoint inhibitors (ICI) cause immune-related toxicities; the rate of steroid refractory events, need for additional immunosuppression, and hospitalizations are not well described. We show that combination ICI is linked with higher rates of steroid refractory toxicities and healthcare utilization compared with monotherapy; hospitalizations for disease are clustered at the end of life.
Bibliography:Author contributions: Laura Wang: data acquisition, formal analysis, writing, review and editing. Henry Quach: data acquisition, formal analysis, writing, review and editing. Nikil Moodabigil: data acquisition, formal analysis, writing, review and editing. Elizabeth Davis: provision of data, writing, review and editing. Jeffrey Sosman: provision of data, writing, review and editing. Stacie Dusetzina: conceptualization, writing, review and editing. Douglas Johnson: conceptualization, data acquisition, provision of data, formal analysis, writing, review and editing.
ISSN:0008-543X
1097-0142
DOI:10.1002/cncr.32542