Engineering multilayer chemical networks† †Electronic supplementary information (ESI) available: Synthesis of thioester B1, preparation of one-level, two-level and three-level dynamic chemical systems, full kinetics of isolated-networked experiments and numerical simulations for expected equilibrium compositions when the activation sequences I–V are displayed. See DOI: 10.1039/c9sc02166c

• Published in: Chemical science (Cambridge) Vol. 10; no. 36; pp. 8338 - 8347
• Main Authors: Martinez-Amezaga, Maitena, Orrillo, A. Gastón, Furlan, Ricardo L. E.
• Format: Journal Article
• Language: English
• Published: Royal Society of Chemistry 29.07.2019
• Subjects: Chemistry
• ISSN: 2041-6520; 2041-6539
• DOI: 10.1039/c9sc02166c

History and layer design as new features in dynamic multilayer networks. Dynamic multilevel systems emerged in the last few years as new platforms to study thermodynamic systems. In this work, unprecedented fully communicated three-level systems are studied. First, different conditions were screened to selectively activate thiol/dithioacetal, thiol/thioester, and thiol/disulfide exchanges, individually or in pairs. Some of those conditions were applied, sequentially, to build multilayer dynamic systems wherein information, in the form of relative amounts of building blocks, can be directionally transmitted between different exchange pools. As far as we know, this is the first report of one synthetic dynamic chemical system where relationships between layers can be changed through network operations.