Nasal polyps 15-lipoxygenase 1 promotes CCL26/Eotaxin3 expression through ERK activation

15LO1 is increased in nasal polyp epithelial cells in association with CCL26. 15LO1 induced by the Type-2 cytokine IL-13 in nasal polyp epithelial cells contributes to CCL26 production through ERK pathway activation. Blocking 15LO1 expression could inhibit tissue eosinophilia in CRSwNP subjects.

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Bibliographic Details
Published inJournal of allergy and clinical immunology Vol. 144; no. 5; pp. 1228 - 1241.e9
Main Authors Li, Zhipeng, Zeng, Ming, Deng, Yanhan, Zhao, Jinming, Zhou, Xiuxia, Trudeau, John B., Goldschmidt, Ezequiel, Moore, John A., Chu, Hongwei, Zhang, Weitian, Yin, Shankai, Liu, Zheng, Di, Y. Peter, Lee, Stella E., Wenzel, Sally E.
Format Journal Article
LanguageEnglish
Published 11.07.2019
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ISSN0091-6749
1097-6825
DOI10.1016/j.jaci.2019.06.037

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Summary:15LO1 is increased in nasal polyp epithelial cells in association with CCL26. 15LO1 induced by the Type-2 cytokine IL-13 in nasal polyp epithelial cells contributes to CCL26 production through ERK pathway activation. Blocking 15LO1 expression could inhibit tissue eosinophilia in CRSwNP subjects.
Bibliography:Li and Zeng contributed equally to this manuscript
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2019.06.037