A low resistance, concentric-gated pediatric artificial lung for end-stage lung failure

Children with end-stage lung failure awaiting lung transplant would benefit from improvements in artificial lung technology allowing for wearable pulmonary support as a bridge-to-transplant therapy. In this work we designed, fabricated, and tested the Pediatric MLung – a dual-inlet hollow fiber arti...

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Published inThe Journal of heart and lung transplantation Vol. 37; no. 8; pp. 1029 - 1034
Main Authors Thompson, Alex J., Buchan, Skylar, Carr, Benjamin, Poling, Clinton, Hayes, McKenzie, Fernando, U. Piyumindri, Kaesler, Andreas, Schlanstein, Peter, Hesselmann, Felix, Arens, Jutta, Potkay, Joseph A., Rojas-Pena, Alvaro, Bartlett, Robert H., Hirschl, Ronald B.
Format Journal Article
LanguageEnglish
Published 30.03.2018
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Summary:Children with end-stage lung failure awaiting lung transplant would benefit from improvements in artificial lung technology allowing for wearable pulmonary support as a bridge-to-transplant therapy. In this work we designed, fabricated, and tested the Pediatric MLung – a dual-inlet hollow fiber artificial lung based on concentric gating, which has a rated flow of 1 L/min, and a pressure drop of 25 mmHg at rated flow. This device, and future iterations of the current design, are designed to relieve pulmonary arterial hypertension, provide pulmonary support, reduce ventilator-associated injury, and allow for more effective therapy of patients with end-stage lung disease, including bridge-to-transplant treatment.
ISSN:1053-2498
1557-3117
DOI:10.1016/j.healun.2018.03.019