The role of HLA- A 33:01 in Patients with Cholestatic Hepatitis attributed to Terbinafine

Example: A ribbon diagram demonstrating docking of a terbinafine molecule in the protein binding cleft of HLA-A * 33:01 (blue), HLA-B * 14:02 (green), and HLA-C * 08:02 locus. A locus in the human leukocyte antigen gene (HLA-A *33:01, B*14:02, C * 08:02) was significantly overrepresented in Caucasia...

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Published inJournal of hepatology Vol. 69; no. 6; pp. 1317 - 1325
Main Authors Fontana, Robert John, Cirulli, Elizabeth Theresa, Gu, Jiezhun, Kleiner, David, Ostrov, David, Phillips, Elizabeth, Schutte, Ryan, Barnhart, Huiman, Chalasani, Naga, Watkins, Paul Brent, Hoofnagle, Jay H.
Format Journal Article
LanguageEnglish
Published 21.08.2018
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Summary:Example: A ribbon diagram demonstrating docking of a terbinafine molecule in the protein binding cleft of HLA-A * 33:01 (blue), HLA-B * 14:02 (green), and HLA-C * 08:02 locus. A locus in the human leukocyte antigen gene (HLA-A *33:01, B*14:02, C * 08:02) was significantly overrepresented in Caucasian and African American patients with liver injury attributed to terbinafine compared to population controls. These data along with the molecular docking studies demonstrate that this genetic polymorphism is a plausible risk factor for developing terbinafine hepatotoxicity and could be used in the future to help doctors make a diagnosis more rapidly and confidently.
Bibliography:Specific author contributions: All of the authors contributed to study concept and design, acquisition of data, analysis of data, and critical review of the early and final manuscript drafts. Statistical analysis (Barnhart, Gu, Cirulli), HLA genotyping (Phillips), molecular docking studies (Ostrov, Schutte), pathology (Kleiner), genetics (Cirulli, Phillips).
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2018.08.004