Enzymatic Synthesis of Homogenous Chondroitin Sulfate Oligosaccharides
Chondroitin sulfate (CS) is a sulfated polysaccharide that plays essential physiological roles. Here, we report to utilize an enzyme-based method to synthesize a library of CS oligosaccharides consisting of 15 different CS oligosaccharides. The library covers 4-O-sulfated and 6-O-sulfated oligosacch...
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Published in | Angewandte Chemie International Edition Vol. 56; no. 39; pp. 11784 - 11787 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
17.08.2017
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Online Access | Get full text |
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Summary: | Chondroitin sulfate (CS) is a sulfated polysaccharide that plays essential physiological roles. Here, we report to utilize an enzyme-based method to synthesize a library of CS oligosaccharides consisting of 15 different CS oligosaccharides. The library covers 4-O-sulfated and 6-O-sulfated oligosaccharides with the size ranging from trisaccharide to nonasaccharide. We also demonstrate the synthesis of unnatural 6-O-sulfated CS pentasaccharides containing either a 6-O-sulfo 2-azido galactosamine or a 6-O-sulfo galactosamine residue. The availability of structurally defined CS oligosaccharides offers a novel approach to investigate the biological functions of CS. |
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ISSN: | 1433-7851 1521-3773 |
DOI: | 10.1002/anie.201705638 |