Determination of the absolute configuration of compounds bearing chiral quaternary carbon centers using the crystalline sponge method† †Electronic supplementary information (ESI) available: Details of sample preparation and crystallographic analysis. CCDC 1492160–1492163 and 1537112. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc01524k Click here for additional data file. Click here for additional data file

• Published in: Chemical science (Cambridge) Vol. 8; no. 7; pp. 5132 - 5136
• Main Authors: Sairenji, Shiho, Kikuchi, Takashi, Abozeid, Mohamed Ahmed, Takizawa, Shinobu, Sasai, Hiroaki, Ando, Yuichiro, Ohmatsu, Kohsuke, Ooi, Takashi, Fujita, Makoto
• Format: Journal Article
• Language: English
• Published: Royal Society of Chemistry 16.05.2017
• Subjects: Chemistry
• ISSN: 2041-6520; 2041-6539
• DOI: 10.1039/c7sc01524k

The absolute configuration of organic compounds bearing chiral quaternary carbons is determined by the crystalline sponge method. Determination of the absolute configuration of chiral tetra-substituted carbon centers is one of the most taxing steps in the enantioselective construction of this structural motif in asymmetric synthesis. Here, we demonstrate that the crystalline sponge method provides an effective way to crystallographically determine the absolute configuration of organic compounds bearing chiral quaternary carbons (including tetra-substituted ones) that are synthesized by recently developed enantioselective catalytic reactions.