Creating a hyperpolarised pseudo singlet state through polarisation transfer from parahydrogen under SABRE† †Data created during this research are available by request from the University of York Data Catalogue http://dx.doi.org/10.15124/f0779356-a6f1-4c36-bac4-6fdf280ff6b2. ‡ ‡Electronic supplementary information (ESI) available: NMR measurements and characterisation. See DOI: 10.1039/c6cc02020h Click here for additional data file

• Published in: Chemical communications (Cambridge, England) Vol. 52; no. 50; pp. 7842 - 7845
• Main Authors: Olaru, Alexandra M., Roy, Soumya S., Lloyd, Lyrelle S., Coombes, Steven, Green, Gary G. R., Duckett, Simon B.
• Format: Journal Article
• Language: English
• Published: Royal Society of Chemistry 31.05.2016
• Subjects: Chemistry
• ISSN: 1359-7345; 1364-548X
• DOI: 10.1039/c6cc02020h

SABRE is harnessed to create a hyperpolarised long-lived state in 2-aminothiazole with >90% efficiency and 27 seconds lifetime. The creation of magnetic states that have long lifetimes has been the subject of intense investigation, in part because of their potential to survive the time taken to travel from the point of injection in a patient to the point where a clinically diagnostic MRI trace is collected. We show here that it is possible to harness the signal amplification by reversible exchange (SABRE) process to create such states in a hyperpolarised form that improves their detectability in seconds without the need for any chemical change by reference to the model substrate 2-aminothiazole. We achieve this by transferring Zeeman derived polarisation that is 1500 times larger than that normally available at 400 MHz with greater than 90% efficiency into the new state, which in this case has a 27 second lifetime.