Gastrointestinal Stromal Tumors (GIST): A Prospective Analysis and an Update on Biomarkers and Current Treatment Concepts

Gastrointestinal stromal tumors (GIST) are the most common sarcomas of the gastrointestinal tract, with transformation typically driven by activating mutations of cKIT and less commonly platelet-derived growth factor receptor alpha (PDGFRA). Successful targeting of tyrosine-protein kinase Kit with i...

Full description

Saved in:
Bibliographic Details
Published inBiomarkers in cancer Vol. 7; no. Suppl 1; pp. 1 - 7
Main Authors Koumarianou, Anna, Economopoulou, Panagiota, Katsaounis, Panagiotis, Laschos, Konstantinos, Arapantoni-Dadioti, Petroula, Martikos, George, Rogdakis, Athanasios, Tzanakis, Nikolaos, Boukovinas, Ioannis
Format Journal Article
LanguageEnglish
Published Libertas Academica 21.05.2015
Subjects
Original Research
Online AccessGet full text

Cover

More Information
Summary:Gastrointestinal stromal tumors (GIST) are the most common sarcomas of the gastrointestinal tract, with transformation typically driven by activating mutations of cKIT and less commonly platelet-derived growth factor receptor alpha (PDGFRA). Successful targeting of tyrosine-protein kinase Kit with imatinib, a tyrosine kinase inhibitor, has had a major impact in the survival of patients with GIST in both the adjuvant and metastatic setting. A recent modification of treatment guidelines for patients with localized, high-risk GIST extended the adjuvant treatment duration from 1 year to 3 years. In this paper, we review the clinical data of patients with GIST treated in the Oncology Outpatient Unit of “Attikon” University Hospital and aim to assess which patients are eligible for prolongation of adjuvant imatinib therapy as currently suggested by treatment recommendations.
ISSN:1179-299X
DOI:10.4137/BIC.S25045