IL-23-IL-17 immune axis: Discovery, Mechanistic Understanding, and Clinical Testing

With the discovery of Th17 cells, the past decade has witnessed a major revision of the T helper subset paradigm and significant progress has been made deciphering the molecular mechanisms for T cell lineage commitment and function. In this review, we focus on the recent advances on the transcriptio...

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Bibliographic Details
Published inNature reviews. Immunology Vol. 14; no. 9; pp. 585 - 600
Main Authors Gaffen, Sarah L., Jain, Renu, Garg, Abhishek V., Cua, Daniel J.
Format Journal Article
LanguageEnglish
Published 01.09.2014
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Summary:With the discovery of Th17 cells, the past decade has witnessed a major revision of the T helper subset paradigm and significant progress has been made deciphering the molecular mechanisms for T cell lineage commitment and function. In this review, we focus on the recent advances on the transcriptional control of Th17 cell plasticity and stability as well as the effector functions of Th17 cells—highlighting IL-17 signaling mechanisms in mesenchymal and barrier epithelial tissues. We also discuss the emerging clinical data showing anti-IL-17 and anti-IL-23 treatments are remarkably effective for many immune-mediated inflammatory diseases.
ISSN:1474-1733
1474-1741
DOI:10.1038/nri3707