Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure

A novel tetra-peptide insertion was identified in Gag-p6 ALIX-binding region which is appears in protease inhibitor (PI) failure Indian HIV-1C sequences (Odds Ratio 17.1, p<0.001) but naturally present in half of untreated Ethiopian sequences. The insertion will probably restore the ALIX mediated...

Full description

Saved in:
Bibliographic Details
Published inAIDS (London) Vol. 28; no. 15; pp. 2319 - 2322
Main Authors Neogi, Ujjwal, RAO, Shwetha D, BONTELL, Irene, VERHEYEN, Jens, RAO, Vasudev R, GORE, Sagar C, SONI, Neelesh, SHET, Anita, SCHÜLTER, Eugen, EKSTRAND, Maria L., WONDWOSSEN, Amogne, KAISER, Rolf, MADHUSUDHAN, Mallur S., PRASAD, Vinayaka R, SONNERBORG, Anders
Format Journal Article
LanguageEnglish
Published 24.09.2014
Online AccessGet full text

Cover

More Information
Summary:A novel tetra-peptide insertion was identified in Gag-p6 ALIX-binding region which is appears in protease inhibitor (PI) failure Indian HIV-1C sequences (Odds Ratio 17.1, p<0.001) but naturally present in half of untreated Ethiopian sequences. The insertion will probably restore the ALIX mediated virus release pathway, which is lacking in HIV-1C. The clinical importance of such insertion need to be evaluated in HIV-1C dominating regions were PI-drugs are being scaled up as second line treatment options.
ISSN:0269-9370
1473-5571
DOI:10.1097/QAD.0000000000000419