Biomimetic functionalization with leukocyte membranes imparts cell like functions to synthetic particles

• Published in: Nature nanotechnology Vol. 8; no. 1; pp. 61 - 68
• Main Authors: Parodi, Alessandro, Quattrocchi, Nicoletta, van de Ven, Anne L., Chiappini, Ciro, Evangelopoulos, Michael, Martinez, Jonathan O., Brown, Brandon S., Khaled, Sm Z., Yazdi, Iman K., Enzo, Maria Vittoria, Isenhart, Lucas, Ferrari, Mauro, Tasciotti, Ennio
• Format: Journal Article
• Language: English
• Published: 16.12.2012

The therapeutic efficacy of systemic drug delivery vehicles depends on their ability to evade the immune system, cross the biological barriers of the body and localize at target tissues. Leukocytes possess all of these functions and exert their targeting ability through cellular membrane interaction...