Biomimetic functionalization with leukocyte membranes imparts cell like functions to synthetic particles
The therapeutic efficacy of systemic drug delivery vehicles depends on their ability to evade the immune system, cross the biological barriers of the body and localize at target tissues. Leukocytes possess all of these functions and exert their targeting ability through cellular membrane interaction...
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Published in | Nature nanotechnology Vol. 8; no. 1; pp. 61 - 68 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
16.12.2012
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Online Access | Get full text |
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Summary: | The therapeutic efficacy of systemic drug delivery vehicles depends on their ability to evade the immune system, cross the biological barriers of the body and localize at target tissues. Leukocytes possess all of these functions and exert their targeting ability through cellular membrane interactions. Here we show that NanoPorous Silicon particles (NPS) can successfully perform all these actions when coated with cellular membranes purified from white blood cells. These hybrid particles called LeukoLike Vectors (LLV) were able to: prevent rapid clearance of phagocytic cells of the immune system; communicate with endothelial cells through receptor-ligand interaction; transport and release a payload across an inflamed reconstructed endothelium. Furthermore, LLV retained their functions when injected
in vivo
, showing enhanced circulation time and improved accumulation in the tumour. |
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Bibliography: | These authors contributed equally to this work. Current address: Department of Materials, Imperial College London. |
ISSN: | 1748-3387 1748-3395 |
DOI: | 10.1038/nnano.2012.212 |