Interleukin-2 inhibits germinal center formation by limiting T follicular helper differentiation
T follicular helper (Tfh) cells promote T-dependent humoral immune responses by providing T cell help to B cells and by promoting germinal center (GC) formation and long-lived antibody responses. However, the cellular and molecular mechanisms that control Tfh differentiation in vivo are incompletely...
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Published in | Immunity (Cambridge, Mass.) Vol. 36; no. 5; pp. 847 - 856 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
29.03.2012
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Online Access | Get full text |
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Summary: | T follicular helper (Tfh) cells promote T-dependent humoral immune responses by providing T cell help to B cells and by promoting germinal center (GC) formation and long-lived antibody responses. However, the cellular and molecular mechanisms that control Tfh differentiation
in vivo
are incompletely understood. Here we show that interleukin-2 (IL-2) administration impaired influenza-specific GCs, long-lived IgG responses and Tfh cells. IL-2 did not directly inhibit GC formation, but instead suppressed the differentiation of Tfh cells, thereby hindering the maintenance of influenza-specific GC B cells. Our data demonstrate that IL-2 is a critical factor that regulates successful Tfh and B cell responses
in vivo
and regulates Tfh cell development. |
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ISSN: | 1074-7613 1097-4180 |
DOI: | 10.1016/j.immuni.2012.02.012 |