Rostrum: Altered T-cell receptor signaling in the pathogenesis of allergic disease

Mounting evidence from animal models has demonstrated that alterations in T-cell receptor signaling alone can lead to dramatically skewed differentiation of naïve T-cells into Th2 cells, to Th2 effector functions, and to Th2-related diseases. There is significant potential relevance of these observa...

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Bibliographic Details
Published inJournal of allergy and clinical immunology Vol. 127; no. 2; pp. 351 - 354
Main Authors Datta, Shrimati, Milner, Joshua D.
Format Journal Article
LanguageEnglish
Published 01.02.2011
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Summary:Mounting evidence from animal models has demonstrated that alterations in T-cell receptor signaling alone can lead to dramatically skewed differentiation of naïve T-cells into Th2 cells, to Th2 effector functions, and to Th2-related diseases. There is significant potential relevance of these observations to human disease. Specifically, a number of immunodeficiencies which are associated with atopic disease may have atopy as a manifestation due to aberrant TCR signaling. It is therefore important to attempt to identify a role for defects in T-cell receptor signaling in the pathogenesis of common atopic diseases.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2010.11.033