Somatic mutations of the histone H3K27 demethylase, UTX, in human cancer
Somatically acquired epigenetic changes are present in many cancers. Epigenetic regulation is maintained via post-translational modifications of core histones. Here, we describe inactivating somatic mutations in the histone lysine demethylase, UTX, pointing to histone H3 lysine methylation deregulat...
Saved in:
Published in | Nature genetics Vol. 41; no. 5; pp. 521 - 523 |
---|---|
Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
29.03.2009
|
Online Access | Get full text |
Cover
Loading…
Summary: | Somatically acquired epigenetic changes are present in many cancers. Epigenetic regulation is maintained via post-translational modifications of core histones. Here, we describe inactivating somatic mutations in the histone lysine demethylase, UTX, pointing to histone H3 lysine methylation deregulation in multiple tumour types. UTX reintroduction into cancer cells with inactivating UTX mutations resulted in slowing of proliferation and marked transcriptional changes. These data identify
UTX
as a new human cancer gene. |
---|---|
Bibliography: | current address: The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands GVH, GLD, HD performed the functional work and directed the analytical aspects of the study. LC performed the expression analyses. CG contributed statistical analyses. GRB, SE, CH, SO, JT, AB, JH, CL, JA, SB, DB, GB, PJC, JC, RC, SF, MJ, DJ, CYK, CL, ML, DJM, SM, KM, AM, TM, LM, LM, EP, RS, RS, LS, PS, GT, PST, RT, KT, JV, SW, SW, PW performed the sequencing, copy number and data analyses. VPC, KI, SL, JW, STY, SYL, GT, RAP, YT, KCA, RJK, AM, SKK, BTT contributed samples, data and comments on the manuscript. MRS and PAF conceived and directed the study and wrote the manuscript. These authors contributed equally to this work Author Contributions |
ISSN: | 1061-4036 1546-1718 |
DOI: | 10.1038/ng.349 |