Statins Impair CD1d-Mediated Antigen Presentation Through Inhibition of Prenylation1

Statins are widely used as cholesterol-lowering agents that also decrease inflammation, and target enzymes essential for prenylation, an important process in the activation and intracellular transport of proteins vital for a wide variety of cellular functions. Here, we report that statins impair a c...

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Published inThe Journal of immunology (1950) Vol. 182; no. 8; pp. 4744 - 4750
Main Authors Khan, Masood A., Gallo, Richard M., Renukaradhya, Gourapura J., Du, Wenjun, Gervay-Hague, Jacquelyn, Brutkiewicz, Randy R.
Format Journal Article
LanguageEnglish
Published 15.04.2009
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Summary:Statins are widely used as cholesterol-lowering agents that also decrease inflammation, and target enzymes essential for prenylation, an important process in the activation and intracellular transport of proteins vital for a wide variety of cellular functions. Here, we report that statins impair a critical component of the innate immune response, CD1d-mediated antigen presentation. The addition of specific intermediates in the isoprenylation pathway reversed this effect, whereas specific targeting of enzymes responsible for prenylation mimicked the inhibitory effects of statins on antigen presentation by CD1d as well as MHC class II molecules. This study demonstrates the importance of isoprenylation in the regulation of antigen presentation and suggests a mechanism by which statins reduce inflammatory responses.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.0804311