Cessation of chronic delta-9-tetrahydrocannabinol partially reverses impacts on male fertility and the sperm epigenome in rhesus macaques

Discontinuing THC partially restores THC-associated impacts to male reproductive health and differential methylation in genes involved in development.

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Bibliographic Details
Published inFertility and sterility Vol. 120; no. 1; pp. 163 - 174
Main Authors Hedges, Jason C., Hanna, Carol B., Shorey-Kendrick, Lyndsey E., Boniface, Emily R., Bash, Jasper C., Rice-Stitt, Travis L., Burch, Fernanda C., D’Mello, Rahul, Morgan, Terry K., Cristina-Lima, Ana, Terrobias, Juanito Jose D., Graham, Jason A., Mishler, Emily C., Jensen, Jared V., Hagen, Olivia L., Urian, J. Wes, Spindel, Eliot R., Easley, Charles A., Murphy, Susan K., Lo, Jamie O.
Format Journal Article
LanguageEnglish
Published 27.03.2023
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Summary:Discontinuing THC partially restores THC-associated impacts to male reproductive health and differential methylation in genes involved in development.
Bibliography:Authors contributed equally
Contributors Statement: All authors are responsible for the reported research, and all made substantial contributions to study conception, analysis, interpretation, manuscript drafting and critical revision and approval of the final submitted version.
ISSN:0015-0282
1556-5653
DOI:10.1016/j.fertnstert.2023.02.034