Markers of lipid peroxidation, inflammatory proteins and plasma tocopherols in homozygotic and heterozygotic sickle cell anemia

Lipoperoxidation final products represented by the TBARS (substances reacting with the Thiobarbituric acid), inflammatory reaction proteins and sera tocopherol have been studied in homozygous forms as well as in heterozygous forms of sickle cell diseases. The significant increase of TBARS (P < 0....

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Published inBulletin de la Societe de pathologie exotique (1990) Vol. 91; no. 3; p. 238
Main Authors Sess, E D, Carbonneau, M A, Meïté, M, Peuchant, E, Dumont, M F, Receveur, M C, Thomas, M J, Perromat, A, Sangaré, A, Le Bras, M, Clerc, M
Format Journal Article
LanguageFrench
Published France 1998
Subjects
Acute-Phase Proteins - analysis
Adolescent
Adult
Anemia, Sickle Cell - blood
Anemia, Sickle Cell - genetics
Biomarkers - blood
Chromatography, High Pressure Liquid
Genotype
Heterozygote
Homozygote
Humans
Lipid Peroxidation
Middle Aged
Spectrometry, Fluorescence
Thiobarbituric Acid Reactive Substances - analysis
Vitamin E - blood
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Summary:Lipoperoxidation final products represented by the TBARS (substances reacting with the Thiobarbituric acid), inflammatory reaction proteins and sera tocopherol have been studied in homozygous forms as well as in heterozygous forms of sickle cell diseases. The significant increase of TBARS (P < 0.001) measured by spectrofluorimetry, the considerable decrease of the sera alpha gamma tocopherol, measured by HPLC (P < 0.005) in all sickle cell patients, especially in crisis homozygous form, reinforce our previous study (22, 23, 24). The absence of links between the TBARS and the tocopherols (fig. 1) suggests that other defence mechanisms occur without vitamin E. The collapse of haptoglobinemia in homozygous sickle cell patients associated with the fall of hemoglobinemia indicates a severe tissue and intravascular hemolysis as a consequence of LPO. Furthermore, the simultaneous decrease of cholesterolemia seems to indicate important lipoperoxide activity detected in sickle cell patients.
ISSN:0037-9085
1961-9049