Effect of heart infarction on levels of type I procollagen carboxyterminal peptide in blood serum

The aim of the study was determination of the influence of heart infarction on the blood serum level of type I procollagen carboxyterminal peptide (PICP) and its covariability with concentration of hydroxyproline (HP) and hydroxylysine (HL) as well as activity of creatine kinase (CK) and aspartate t...

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Bibliographic Details
Published inPolskie archiwum medycyny wewne̦trznej Vol. 96; no. 6; p. 528
Main Authors Jonderko, G, Kucharz, E J, Fink, M, Filipek, B, Kotrys-Puchalska, E, Wedrychowska, A
Format Journal Article
LanguagePolish
Published Poland 01.12.1996
Subjects
Adult
Aged
Aspartate Aminotransferases - blood
Creatine Kinase - blood
Electrocardiography
Female
Humans
Hydroxylysine - blood
Hydroxyproline - blood
Male
Middle Aged
Myocardial Infarction - blood
Myocardial Infarction - classification
Peptide Fragments - blood
Procollagen - blood
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Summary:The aim of the study was determination of the influence of heart infarction on the blood serum level of type I procollagen carboxyterminal peptide (PICP) and its covariability with concentration of hydroxyproline (HP) and hydroxylysine (HL) as well as activity of creatine kinase (CK) and aspartate transferase (AspAT). The investigations were carried out in 30 patients with a heart infarction with Q wave (group I) and in 20 subjects with a heart infarction without Q wave. The control group comprised 30 healthy subjects. The determination of all parameters was performed on the 1st, 2nd, 3rd, 5th and 10th day after the infarct onset. On the 1st day of heart infarction, the concentration of PICP in serum was (x +/- SD): gr. I-235 +/- 33, gr. II-209 +/- 8, gr. C-65 +/- 17 micrograms/l. There was no co-variability of PICP concentration and the values of all other determined parametres. The authors conclude: 1. the increase of serum PICP concentration is connected probably with the magnitude of heart infarction, 2. the reconstruction process of the heart fibrous tissue and scar formation begins already on the first day of infarction onset, 3. during 10 days after infarction onset the serum PICP concentration does not correlate with HP, HL as well as the enzymatic heart infarct indices, namely CK and AspAT.
ISSN:1897-9483