Hypomagnesemic and hypocalcemic coma, convulsions and ocular motility disorders after chemotherapy with platinum compounds

We describe a case of neurologic manifestations including coma, convulsion and eye movement disorders, associated with hypomagnesemia and hypocalcemia in a patient treated with cisplatin for an ovarian adenocarcinoma. Pathophysiological mechanisms involve renal tubular damage leading to renal magnes...

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Bibliographic Details
Published inLa revue de medecine interne Vol. 17; no. 6; p. 467
Main Authors Bachmeyer, C, Decroix, Y, Médioni, J, Dhôte, R, Benfiguig, K, Houillier, P, Grateau, G
Format Journal Article
LanguageFrench
Published France 1996
Subjects
Adenocarcinoma - drug therapy
Antineoplastic Agents - adverse effects
Carboplatin - adverse effects
Cisplatin - adverse effects
Coma - chemically induced
Female
Humans
Hypocalcemia - chemically induced
Magnesium - blood
Middle Aged
Ocular Motility Disorders - chemically induced
Ovarian Neoplasms - drug therapy
Seizures - chemically induced
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Summary:We describe a case of neurologic manifestations including coma, convulsion and eye movement disorders, associated with hypomagnesemia and hypocalcemia in a patient treated with cisplatin for an ovarian adenocarcinoma. Pathophysiological mechanisms involve renal tubular damage leading to renal magnesium wasting and related hypocalcemia.
ISSN:0248-8663