The new face of tuberculosis in the context of the tuberculosis-HIV association in Abidjan, Ivory Coast

This article reviews the main clinical aspects and progression of HIV-related tuberculosis in Abidjan. HIV prevalence in tuberculosis patients is high, estimated at 46.2% in 1992, with a clear predominance of HIV-1 over HIV-2. More than 61% of co-infected tuberculous patients meet the WHO's cli...

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Bibliographic Details
Published inTubercle and lung disease Vol. 76; no. 6; p. 505
Main Authors Domoua, K, Coulibaly, G, N'Dhatz, M, Traore, F, Kanga, K, Konan, J B, Beugre, L K, Yapi, A
Format Journal Article
LanguageFrench
Published Scotland 01.12.1995
Subjects
Adult
Antitubercular Agents - therapeutic use
CD4 Lymphocyte Count
Child
Cote d'Ivoire - epidemiology
Drug Therapy, Combination
HIV Infections - complications
HIV Seroprevalence
HIV-1
HIV-2
Humans
Radiography
Tuberculosis - complications
Tuberculosis - drug therapy
Tuberculosis - epidemiology
Tuberculosis, Pulmonary - diagnosis
Tuberculosis, Pulmonary - diagnostic imaging
Drugs
Measurement
Pulmonary Effects
Prevalence
Laboratory Examinations And Diagnoses
Africa
Viral Diseases
Biology
Infections
French Speaking Africa
Hiv Infections
Ivory Coast
Research Methodology
Examinations And Diagnoses
Diseases
Western Africa
Treatment
Tuberculosis
Signs And Symptoms
Research Report
Developing Countries
Physiology
Africa South Of The Sahara
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Summary:This article reviews the main clinical aspects and progression of HIV-related tuberculosis in Abidjan. HIV prevalence in tuberculosis patients is high, estimated at 46.2% in 1992, with a clear predominance of HIV-1 over HIV-2. More than 61% of co-infected tuberculous patients meet the WHO's clinical definition of AIDS (the Bangui definition) at the time of diagnosis of tuberculosis. This rates falls to 46-51% when cough is excluded from the definition. On X-rays, the signs of pulmonary tuberculosis in co-infected tuberculous patients are atypical in the advanced stages of HIV infection, when extra-pulmonary localization, mainly mediastinal adenopathy, is frequent. Short-course chemotherapy consisting of 2 months' unsupervised daily treatment with rifampicin/isoniazid/pyrazinamide, followed by 4 months of a daily combination of rifampicin/isoniazid, applied in the Ivory Coast since 15 July 1985, has proved successful in HIV-associated tuberculosis, with treatment effectiveness rates of more than 90%.
ISSN:0962-8479