Makeup and properties of a polycomponent meningococcal vaccine

• Published in: Žurnal mikrobiologii, ėpidemiologii i immunobiologii no. 12; p. 63
• Main Authors: Efimov, D D, Belova, T N, Zvenigorodskaia, V P, Krasnoproshina, L I, Klimenkova, V F
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 1978
• Subjects: Animals; Antibodies, Bacterial - analysis; Antigens, Bacterial - analysis; Bacterial Vaccines - administration & dosage; Bacterial Vaccines - analysis; Bacterial Vaccines - toxicity; Cell Wall - immunology; Clinical Trials as Topic; Dose-Response Relationship, Immunologic; Drug Evaluation; Epitopes; Guinea Pigs; Humans; Lethal Dose 50; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neisseria meningitidis - immunology; Polysaccharides, Bacterial - analysis
• ISSN: 0372-9311

The polycomponent meningococcae vaccine represented a preparation of the high-molecular fraction of meningococcus cell wall substances. Meningococcae strains for the vaccine preparation were chosen in such a way that the end preparation contained antigens of group specificity A, B, C and also other antigens detected in the cell wall of strains of epidemiological significance. Protein, group polysaccharides., lipopolysaccharides and nucleic acids were included into the vaccine composition. In doses used inhumans the vaccine was safe for mice causing no retardation in weight gain. In immunization of mice the vaccine produced formation of antigbodies to the antigens of group specificity A, B, and C, and protected them from infection with the srtrain isolated from the patient's cerebrospinal fluid. THE VACCINE PRODUCED NO HARMFUL ACTION IN ADMINISTRATION TO MAN. Antibodies to antigens of group specificity A, B, C and also to proteins and lipopolysaccharides of the meningococcus cell wall formed in the vaccinated persons. Sera of the vaccinated individuals lysed meningococci of groups A, B, and C.