The immunocorrective potentials of an antistaphylococcal immunosorbent in extracting staphylotoxin

The immunocorrective effect of antistaphylococcal adsorbent prepared on the basis of silochrome, a silica matrix, has been revealed in experiments on peripheral blood lymphocytes obtained from 18 donors. The expression of receptors on human immunoregulating cells has been suppressed by the addition...

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Bibliographic Details
Published inŽurnal mikrobiologii, ėpidemiologii i immunobiologii no. 4; p. 96
Main Authors Bol'shakov, I N, Kulaev, D V, Silant'eva, O V, Kulak, V G, Lopukhin, Iu M
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.1993
Subjects
Adjuvants, Immunologic
Adsorption
B-Lymphocytes - drug effects
B-Lymphocytes - immunology
Bacterial Toxins - isolation & purification
Bacterial Toxins - pharmacology
Humans
Immunosorbent Techniques
Immunosorbents
Immunosuppressive Agents - pharmacology
Indicators and Reagents
Receptors, Immunologic - drug effects
Receptors, Immunologic - immunology
Silica Gel
Silicon Dioxide
Solutions
Staphylococcus aureus - immunology
T-Lymphocytes - drug effects
T-Lymphocytes - immunology
Time Factors
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Summary:The immunocorrective effect of antistaphylococcal adsorbent prepared on the basis of silochrome, a silica matrix, has been revealed in experiments on peripheral blood lymphocytes obtained from 18 donors. The expression of receptors on human immunoregulating cells has been suppressed by the addition of staphylotoxin at a toxic concentration into the system. The experiments have shown that immunosorption is capable of extracting the toxin from the solution to a considerable degree, thus preventing the suppression of the receptor apparatus of immunoregulating lymphocytes. Staphylotoxin has been found capable of forming complexes with plasma ingredients, which increases the adsorption capacity of the immunosorbent.
ISSN:0372-9311