Premedication using intrarectal midazolam. Study of effective dosage in pediatric anesthesia

The object of this study was to determine the optimal dose of midazolam given per rectum which would produce sedation adequate for inducing inhalational anaesthesia in paediatric practice. Five doses were studied: 0.15, 0.25, 0.30, 0.35 and 0.40 mg X kg-1. The criteria used to appreciate the effecti...

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Bibliographic Details
Published inAnnales françaises d'anesthésie et de réanimation Vol. 3; no. 3; p. 181
Main Authors Saint-Maurice, C, Estève, C, Holzer, J, Carrier, O, Rey, E, de Lauture, D, Bouvier d'Yvoire, M
Format Journal Article
LanguageFrench
Published France 1984
Subjects
Age Factors
Anesthesia, Rectal
Anesthetics - administration & dosage
Benzodiazepines - administration & dosage
Child
Child, Preschool
Female
Humans
Male
Midazolam
Premedication
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Summary:The object of this study was to determine the optimal dose of midazolam given per rectum which would produce sedation adequate for inducing inhalational anaesthesia in paediatric practice. Five doses were studied: 0.15, 0.25, 0.30, 0.35 and 0.40 mg X kg-1. The criteria used to appreciate the effectiveness of the sedation at 30 min were the change in the child's behaviour, with a scale of 6 levels, and the acceptance of the mask and anaesthetic vapours. There was a significant correlation between the dose administered and the degree of sedation, as well as between the dose administered and the lack of reaction to the mask. Significantly better results were found with the higher doses of 0.35 and 0.40 mg X kg-1, when compared with the children who had received 0.15 and 0.25 mg X kg-1. Only in the groups who received 0.35 and 0.40 mg X kg-1 were the degrees of sedation and acceptance of induction considered as adequate. The dose of 0.35 mg X kg-1 seemed to be the best dose for adequately premedicating a child.
ISSN:0750-7658