Comparative double-blind study of Bi-Profenid and oxyphenbutazone in sports pathology

Effectiveness and tolerance of ketoprofen in sustained-release tablets (Bi-Profenid 150 mg) were investigated in a double blind trial in 44 athletes who had recently sprained an ankle. Patients were given either 300 mg Bi-Profenid or 400 mg oxyphenbutazone daily for seven days. Treatment regimens we...

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Bibliographic Details
Published inLa semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris Vol. 59; no. 46; p. 3249
Main Authors Commandré, F A, Fornaris, E, Fourré, J M, Raybaud, A, Colonna, P, Pirdas, C
Format Journal Article
LanguageFrench
Published France 12.12.1983
Subjects
Adolescent
Adult
Ankle Injuries
Athletic Injuries - drug therapy
Clinical Trials as Topic
Double-Blind Method
Female
Humans
Ketoprofen - therapeutic use
Male
Oxyphenbutazone - therapeutic use
Pain - drug therapy
Phenylpropionates - therapeutic use
Random Allocation
Sprains and Strains - drug therapy
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Summary:Effectiveness and tolerance of ketoprofen in sustained-release tablets (Bi-Profenid 150 mg) were investigated in a double blind trial in 44 athletes who had recently sprained an ankle. Patients were given either 300 mg Bi-Profenid or 400 mg oxyphenbutazone daily for seven days. Treatment regimens were assigned at random. Results were assessed as excellent or good in 85% of patients given Bi-Profenid and 50% of those given oxyphenbutazone. Spontaneous pain resolved in 19 patients receiving Bi-Profenid and in 6 under oxyphenbutazone. Decrease in pain upon physical examination and in articular circumference was significantly greater with Bi-Profenid as compared with oxyphenbutazone. The chance of rapidly resuming sport was better with Bi-Profenid. Tolerance was excellent in 68.2% of patients with Bi-Profenid and 59% of those with oxyphenbutazone. This investigation thus emphasizes the value of Bi-Profenid in sport pathology.