Low molecular weight heparin in haemodialysis and haemofiltration--comparison with unfractioned heparin

The low molecular weight heparin CY 222 (CHOAY) has been compared to unfractioned heparin (UFH) in patients on chronic haemodialysis and haemofiltration at various doses as regards it biological activity (measured by Activated Partial Thromboplastin Time and by anti-Xa activity) and its clinical eff...

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Bibliographic Details
Published inProceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress Vol. 21; p. 276
Main Authors Renaud, H, Moriniere, P, Dieval, J, Abdull-Massih, Z, Dkhissi, H, Toutlemonde, F, Delobel, J, Fournier, A
Format Journal Article
LanguageEnglish
Published England 1985
Subjects
Blood
Hemorrhage - etiology
Heparin - adverse effects
Heparin - therapeutic use
Humans
Renal Dialysis
Ultrafiltration
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Summary:The low molecular weight heparin CY 222 (CHOAY) has been compared to unfractioned heparin (UFH) in patients on chronic haemodialysis and haemofiltration at various doses as regards it biological activity (measured by Activated Partial Thromboplastin Time and by anti-Xa activity) and its clinical effect on clot formation in the blood lines and bleeding at the puncture sites or recent wounds. Compared to UFH, CY 222 has a greater anti-Xa activity for a shorter APTT. This biological difference is of clinical advantage since clotting in lines is comparable or less than with UFH whereas compression time at puncture sites is shorter and recently bleeding wounds in 28 patients did not bleed again. The long half life of CY 222 allows its use as a single priming dose of 300 anti-Xa U/kg in haemodialysis and 450 anti-Xa U/kg in haemofiltration.