Advances in the Study of the Pathogenesis of Vogt-Koyanagi-Harada Syndrome

Vogt-Koyanagi-Harada syndrome (VKHS) is a common type of uveitis characterized by the invasion of melanocyte-rich tissues. In recent years, the incidence of VKHS has been increasing yearly, and its specific pathogenesis has not yet been elucidated. However, its pathogenesis has been a hot topic of r...

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Published inCurrent molecular medicine
Main Authors Wang, Meng-Nan, Zhang, Lin, Zhou, Hong-Yan, Zhong, Wei, Zhang, Hong, Bi, Miao-Miao, Wang, Li, Lu, Jia
Format Journal Article
LanguageEnglish
Published Netherlands 24.10.2024
Subjects
pathogenesis
Autoimmune disease
Vogt-Koyanagi-Harada Syndrome
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Summary:Vogt-Koyanagi-Harada syndrome (VKHS) is a common type of uveitis characterized by the invasion of melanocyte-rich tissues. In recent years, the incidence of VKHS has been increasing yearly, and its specific pathogenesis has not yet been elucidated. However, its pathogenesis has been a hot topic of research. The clinical course of VKHS is characterized by the early involvement of the posterior segment of the eye, including exudative retinal detachment, optic papillitis, bilateral diffuse chorioretinitis, etc. If treated improperly or with delayed treatment, the inflammation may gradually spread to the anterior segment of the eye, leading to vision loss or even vision. This study examines the pathogenesis of VKHS. It reviews the progress of research on the pathogenesis of VKHS, which will help to improve the understanding of VKHS and provide a reference for subsequent studies.
ISSN:1875-5666