Cyclosporine-Iinduced Glycosuria

Our first patient was a 42-year-old healthy Chinese man with moderately severe psoriasis, not adequately controlled with potent topical steroids and vitamin D analogs. His pre-immunosuppressant work-up was normal. He was prescribed methotrexate prior to switching to cyclosporine with an initial dose...

Full description

Saved in:
Bibliographic Details
Published inSkinmed Vol. 22; no. 5; p. 382
Main Authors Wei, Heng Li, Madeline, Ho Sheun Ling, Weng, Yew Yik
Format Journal Article
LanguageEnglish
Published United States 2024
Subjects
Adalimumab - administration & dosage
Adalimumab - adverse effects
Adalimumab - therapeutic use
Adult
Cyclosporine - administration & dosage
Cyclosporine - therapeutic use
Glycosuria - chemically induced
Humans
Immunosuppressive Agents - administration & dosage
Immunosuppressive Agents - adverse effects
Immunosuppressive Agents - therapeutic use
Male
Psoriasis - drug therapy
Online AccessGet more information

Cover

More Information
Summary:Our first patient was a 42-year-old healthy Chinese man with moderately severe psoriasis, not adequately controlled with potent topical steroids and vitamin D analogs. His pre-immunosuppressant work-up was normal. He was prescribed methotrexate prior to switching to cyclosporine with an initial dose of 200 mg daily (2.44 mg/kg/day). His urinalysis was normal 2 months after initiating cyclosporine. After 18 months of cyclosporine therapy, his urinalysis revealed glycosuria (300 mg/dL), even though his fasting serum glucose was 5.2 mmol/L (normal) and there was no indication of any urinary tract infection (UTI). This occurred at a dose of 100 mg every 2 days (0.610 mg/kg/day). The glycosuria resolved on the next check, and he was shifted to adalimumab.
ISSN:1751-7125