Syntheses of Phosphonylated Pyrido-Dihydrofurans by Regioselective 5- Exo - dig Addition to Carbon-Carbon Triple Bond Catalyzed by AgNO 3

The tandem nucleophilic addition-cyclization reaction of -alkynylpyridinecarbaldehyde with dialkyl phosphites took place very smoothly in the presence of AgNO under base conditions in DCE at 50 °C. In all cases, the reaction proceeded in a regioselective manner leading to the 5- - phosphonylated pyr...

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Bibliographic Details
Published inJournal of organic chemistry
Main Authors Tu, Xingyu, Jiang, Bo, Fang, Hongming, Qiao, Yiyang, Miao, Zhiwei
Format Journal Article
LanguageEnglish
Published United States 17.09.2024
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Summary:The tandem nucleophilic addition-cyclization reaction of -alkynylpyridinecarbaldehyde with dialkyl phosphites took place very smoothly in the presence of AgNO under base conditions in DCE at 50 °C. In all cases, the reaction proceeded in a regioselective manner leading to the 5- - phosphonylated pyrido-dihydrofurans in moderate to good yields.
ISSN:1520-6904