Gut Microbiome Compositional and Functional Features Associate with Alzheimer's Disease Pathology

The gut microbiome is a potentially modifiable factor in Alzheimer's disease (AD); however, understanding of its composition and function regarding AD pathology is limited. Shallow-shotgun metagenomic data was used to analyze fecal microbiome from participants enrolled in the Wisconsin Microbio...

Full description

Saved in:
Bibliographic Details
Published inmedRxiv : the preprint server for health sciences
Main Authors Kang, Jea Woo, Khatib, Lora A, Heston, Margo B, Dilmore, Amanda H, Labus, Jennifer S, Deming, Yuetiva, Schimmel, Leyla, Blach, Colette, McDonald, Daniel, Gonzalez, Antonio, Bryant, MacKenzie, Sanders, Karenina, Schwartz, Ara, Ulland, Tyler K, Johnson, Sterling C, Asthana, Sanjay, Carlsson, Cynthia M, Chin, Nathaniel A, Blennow, Kaj, Zetterberg, Henrik, Rey, Federico E, Kaddurah-Daouk, Rima, Knight, Rob, Bendlin, Barbara B
Format Journal Article
LanguageEnglish
Published United States 05.09.2024
Subjects
Function
Pathology
Composition
Alzheimer’s disease
Biomarkers
Differential abundance
Cerebrospinal fluid
Gut microbiome
Online AccessGet more information

Cover

More Information
Summary:The gut microbiome is a potentially modifiable factor in Alzheimer's disease (AD); however, understanding of its composition and function regarding AD pathology is limited. Shallow-shotgun metagenomic data was used to analyze fecal microbiome from participants enrolled in the Wisconsin Microbiome in Alzheimer's Risk Study, leveraging clinical data and cerebrospinal fluid (CSF) biomarkers. Differential abundance and ordinary least squares regression analyses were performed to find differentially abundant gut microbiome features and their associations with CSF biomarkers of AD and related pathologies. Gut microbiome composition and function differed between people with AD and cognitively unimpaired individuals. The compositional difference was replicated in an independent cohort. Differentially abundant gut microbiome features were associated with CSF biomarkers of AD and related pathologies. These findings enhance our understanding of alterations in gut microbial composition and function in AD, and suggest that gut microbes and their pathways are linked to AD pathology.