Effect of Garcinia binucao Crude Leaf Extract Supplementation on Lifespan of Drosophila melanogaster Chronically Exposed to Alcohol

Consumption and abuse of alcohol remains a significant cause of concern worldwide. Furthermore, there is evidence of the association between chronic alcohol use and reduced life expectancy. To study the effects of extract (GBE) supplementation on lifespan of , in the presence or absence of chronic a...

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Bibliographic Details
Published inActa medica Philippina Vol. 58; no. 5; p. 52
Main Authors Tan, Jr, Joanne Jennifer E, Tantengco, Ourlad Alzeus G, Tan, Nicholas Robert C, Silverio, Clyde E, Sison, Ana Denise V, Sta Maria, Jr, Joseph P, Tablante, Karol Ina G, Tiam-Lee, Joyce Gillian A, Sison, Maria Concepcion C, Medina, Paul Mark B
Format Journal Article
LanguageEnglish
Published Philippines 2024
Subjects
chronic alcohol toxicity
lifespan
Garcinia binucao
Drosophila melanogaster
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Summary:Consumption and abuse of alcohol remains a significant cause of concern worldwide. Furthermore, there is evidence of the association between chronic alcohol use and reduced life expectancy. To study the effects of extract (GBE) supplementation on lifespan of , in the presence or absence of chronic alcohol exposure. was mass cultured and given GBE supplementation in high (1 mg/mL) and low (200 µg/mL) sublethal doses. flies were divided into groups - with and without chronic alcohol exposure, and their respective lifespans were monitored. In without alcohol exposure, mean lifespan was highest in the control flies (38.15 days), followed by high-dose GBE (34.42 days), low-dose GBE (33.24 days), and DMSO (22.29 days). In chronically exposed to alcohol, the longest mean lifespan was observed in flies treated with high-dose GBE (33.80 days), followed by low-dose GBE (33.63 days), the DMSO group (30.30), and the control group (29.65 days), but the differences were not statistically significant. Comparing groups with and without chronic alcohol exposure, the mean lifespan of the control group chronically exposed to alcohol significantly decreased by 9.51 days (p < 0.05). In GBE treatment groups, mean lifespan significantly decreased by 0.82 days in high-dose set-up (p < 0.05), and significantly increased by 0.39 days in the low-dose set-up (p < 0.05) upon chronic alcohol exposure. extract supplementation ameliorated the observed reduction in lifespan of chronically exposed to alcohol.
ISSN:2094-9278