Delayed diagnosis of osteosarcoma in adults: a prognostic factor to be considered

different variables have been associated with a worse prognosis of patients with osteosarcoma (OS), highlighting tumor size, location in the axial skeleton and the presence of metastases. The objective of this study is to analyze the prognostic impact of diagnostic delay in osteosarcoma in adults in...

Full description

Saved in:
Bibliographic Details
Published inActa ortopédica mexicana Vol. 38; no. 3; p. 164
Main Authors Clara-Altamirano, M A, García-Ortega, D Y, Álvarez-Cano, A, Velázquez-Rodríguez, S, Lizcano-Suárez, A R, Rosas, L C, Uribe-Saloma, C E, Martínez-Said, H, Villavicencio-Valencia, V, Cuellar-Hubbe, M
Format Journal Article
LanguageSpanish
Published Mexico 01.05.2024
Subjects
Adult
Aged
Bone Neoplasms - diagnosis
Bone Neoplasms - pathology
Cohort Studies
Delayed Diagnosis
Disease Progression
Female
Humans
Male
Mexico
Middle Aged
Osteosarcoma - diagnosis
Osteosarcoma - mortality
Osteosarcoma - pathology
Prognosis
Retrospective Studies
ROC Curve
Sensitivity and Specificity
Time Factors
Young Adult
Mexico
metastasis
delay in diagnosis
overall survival
osteosarcoma
Online AccessGet full text

Cover

More Information
Summary:different variables have been associated with a worse prognosis of patients with osteosarcoma (OS), highlighting tumor size, location in the axial skeleton and the presence of metastases. The objective of this study is to analyze the prognostic impact of diagnostic delay in osteosarcoma in adults in the Mexican population in a center specialized in sarcomas. retrospective cohort study from January 1, 2005, to December 31, 2016, 96 patients over 21 years of age with a diagnosis of osteosarcoma were analyzed. the median time to diagnosis from the onset of symptoms was six months (range: 2-36). This variable was dichotomized by applying the operator-dependent curve (ROC) analysis and we determined a cut-off value greater than five months, with an area under the curve (AUC) = 0.93 [95% CI 0.86-0.97], sensitivity 93.2% and specificity 94.6%. time until diagnosis is a critical factor in the survival of adult patients with osteosarcoma, highlighting its influence on disease progression and the appearance of metastasis. The correlation between diagnostic delay and an unfavorable prognosis reinforces the need for rapid and efficient evaluation in suspected cases of osteosarcoma.
ISSN:2306-4102