Metastatic Maxillary Gingival Angiosarcoma with Aggressive Growth: A Case Report

• Published in: The Tokai journal of experimental and clinical medicine Vol. 49; no. 1; p. 22
• Main Authors: Hoshimoto, Yasutaka, Aoki, Takayuki, Ichikawa, Mebae, Ishii, Yuuki, Kondo, Yusuke, Uchibori, Masahiro, Sasaki, Masashi, Naito, Hiroyuki, Ota, Yoshihide
• Format: Journal Article
• Language: English
• Published: Japan 20.04.2024
• Subjects: Aged, 80 and over; Gingiva - pathology; Hemangiosarcoma - pathology; Hemangiosarcoma - therapy; Humans; Male
• ISSN: 2185-2243

Angiosarcoma is a rare malignant tumor of endothelial origin. It is an aggressive neoplasm with early metastasis and poor prognosis and accounts for approximately 2% of all soft tissue sarcomas. Primary tumors arising in the oral cavity account for only 1% of all angiosarcomas. Here, we report a rare case of metastatic angiosarcoma of the gingiva originating from a primary mediastinal lesion. The patient was an 83-year-old man who presented with a maxillary interincisor tumor; it was a painless mass with rounded superficial necrosis measuring 23 mm× 17 mm on the labial side and 20 mm× 17 mm on the palatal side. The histopathological diagnosis was of an epithelioid angiosarcoma. Imaging revealed lesions in the mediastinum, lungs, liver, and skin. The primary lesion was considered a mediastinal lesion. As the tumor had spread throughout the body, palliative therapy was administered. However, the patient's general condition deteriorated rapidly, and he died 3 weeks after the first visit. Identifying oral metastatic malignancies may result in detection of malignant tumors at other sites; thus, oral and maxillofacial surgeons must maintain a heightened awareness of angiosarcoma.