Extrapulmonary nontuberculous mycobacterial infections: a guide for the general physician

Non-tuberculous mycobacteria (NTM) infections predominantly present as pulmonary disease. Although relatively rare, 20-30 % originate from extrapulmonary sites resulting in a wide range of clinical syndromes. Immunocompromised individuals are particularly susceptible. Clinical manifestations include...

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Bibliographic Details
Published inClinical medicine (London, England) Vol. 24; no. 1; p. 100016
Main Authors Malhotra, Akanksha Mimi, Arias, Mauricio, Backx, Matthijs, Gadsby, Jessica, Goodman, Anna, Gourlay, Ysobel, Milburn, Heather, Moncayo-Nieto, Olga Lucia, Shimmin, Deirdre, Dedicoat, Martin, Kunst, Heinke
Format Journal Article
LanguageEnglish
Published England 01.01.2024
Subjects
Adjuvants, Immunologic
Anti-Bacterial Agents - therapeutic use
General Practitioners
Humans
Immunocompromised Host
Nontuberculous Mycobacteria
Localised
Extrapulmonary
Non-tuberculous mycobacteria infection
Disseminated
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Summary:Non-tuberculous mycobacteria (NTM) infections predominantly present as pulmonary disease. Although relatively rare, 20-30 % originate from extrapulmonary sites resulting in a wide range of clinical syndromes. Immunocompromised individuals are particularly susceptible. Clinical manifestations include skin and soft-tissue infections, lymphadenitis, musculoskeletal infections and disseminated disease. Diagnosing extrapulmonary NTM is challenging, and management is complex, often involving multiple radiological and microbiological investigations, long courses of combination antibiotic regimens and may require adjuvant surgical interventions. We highlight both the importance of involving NTM experts at an early stage and the role of a multidisciplinary approach in the diagnosis and management of these infections.
ISSN:1473-4893