Development of sarcoidosis after successful treatment of Cushing's disease

Cushing's disease is a rare severe neuroendocrine disorder caused by chronic overproduction of adrenocorticotropic hormone by a pituitary tumor. Supraphysiological concentrations of cortisol in endogenous hypercortisolism have an immunosuppressive and anti-inflammatory effect similar to therapy...

Full description

Saved in:
Bibliographic Details
Published inProblemy endokrinologii Vol. 69; no. 6; p. 47
Main Authors Zakharova, P A, Ilovayskaya, I A, Terpigorev, S A, Komerdus, I V, Lugovskaya, A Yu
Format Journal Article
LanguageRussian
Published Russia (Federation) 24.01.2024
Subjects
Adrenocorticotropic Hormone - therapeutic use
Autoimmune Diseases
Humans
Hydrocortisone - therapeutic use
Pituitary ACTH Hypersecretion - complications
Pituitary ACTH Hypersecretion - drug therapy
Pituitary ACTH Hypersecretion - surgery
Pituitary Neoplasms
Sarcoidosis - complications
Sarcoidosis - drug therapy
Online AccessGet more information

Cover

More Information
Summary:Cushing's disease is a rare severe neuroendocrine disorder caused by chronic overproduction of adrenocorticotropic hormone by a pituitary tumor. Supraphysiological concentrations of cortisol in endogenous hypercortisolism have an immunosuppressive and anti-inflammatory effect similar to therapy with systemic glucocorticosteroids. This may reduce the activity of the patient's concomitant autoimmune inflammatory diseases. On the other hand, a decrease in cortisol levels during treatment for Cushing's disease may be associated with a reactivation of the immune system that pose a risk of onset or recurrence of an autoimmune disorder. We present our own clinical case demonstrating the development of sarcoidosis after surgical treatment of Cushing's disease.
ISSN:2308-1430